Those variables with p values below 0.05 in the final model were judged to be independent predictors of mortality.Ĭontinuous variables are expressed as means ± standard deviation. To determine independent predictors of mortality, those variables exhibiting p values below 0.1 in the univariable analyses entered into a multivariable Cox-regression analysis (forward stepwise likelihood ratio). Therefore, the aim of this study is to determine whether the native lung after SLT could be the source of morbidity and mortality that might explain, at least in part, the longer survival of BLT. However, there is little evidence demonstrating that the native lung could be the cause of a worst survival after a SLT. The longer survival of BLT has been related to a better postoperative lung function and less chronic lung allograft dysfunction (CLAD) compared with unilateral procedures.
ĭespite all this, the topic remains controversial, and some authors still recommend performing SLT in older patients with specific diseases such as pulmonary fibrosis, especially given the limited organ availability and the unacceptable mortality rate while on the waiting list. Nonetheless, in the last decade, this trend has been inverted, and BLT is the most frequently performed after demonstrating better survival, among other several advantages in comparison with SLT. In the first lung transplant era, SLT was the procedure of choice. After more than 40 years of worldwide clinical experience, both single (SLT) and bilateral lung transplants (BLT) are widely accepted, and its selection rely on clinical features, such as age, pulmonary arterial pressure or infectious status. Lung transplantation is a well established, and lifesaving treatment for end-stage pulmonary diseases, especially in whom all medical treatment has failed. The presence of late native lung problems predicted survival in COPD patients (OR: 2.55 p = 0.07). 33☙6 days p<0.001), longer postoperative intubation (41☘5 vs. Native lung complications were associated to longer ICU stay (10☑7 vs. with late complications: COPD (89%, 86%, 80% vs. Twelve patients died due to a native lung complication (7.4% of patients 24% of all deaths).
Thirty-day mortality did not differ between patients with or without early complications (6% vs. Forty-nine patients (30%) presented complications in the native lung. There were 161 patients (126M/35F 57☗ years) transplanted for emphysema (COPD) (n = 72), pulmonary fibrosis (IPF) (n = 77), or other indications (n = 12).
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